Contents

Preface v

Contributors ix

PART I. OPIOID ADDICTION

1 Molecular Mechanisms of Opioid Dependence by Using Knockout Mice

Brigitte L. Kieffer and Frédéric Simonin 3

2 Molecular Genetic Approaches

Theo Mantamadiotis, Günther Schütz, and Rafael Maldonado 27

3 Opiate Addiction: Role of the cAMP Pathway and CREB

Lisa M. Monteggia and Eric J. Nestler 37

4 Different Intracellular Signaling Systems

Involved in Opioid Tolerance/Dependence

Thomas Koch, Stefan Schulz, and Volker Höllt 45

5 Inhibitors of Enkephalin Catabolism:

New Therapeutic Tool in Opioid Dependence

Florence Noble and Bernard P. Roques 61

PART II. PSYCHOSTIMULANT ADDICTION

6 Recent Advances in the Molecular Mechanisms of Psychostimulant Abuse Using Knockout Mice

Cécile Spielewoy and Bruno Giros 79

7 Opioid Modulation of Psychomotor Stimulant Effects

Toni S. Shippenberg and Vladimir I. Chefer 107

8 Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulants

Michela Marinelli and Pier Vincenzo Piazza 133

viii Contents

9 Development and Expression of Behavioral Sensitization: Temporal Profile of Changes in Gene Expression

Peter W. Kalivas 161

PART III. CANNABINOID ADDICTION

10 New Advances in the Identification and Physiological Roles of the Components of the Endogenous Cannabinoid System

Ester Fride and Raphael Mechoulam 173

11 Integration of Molecular and Behavioral Approaches to Evaluate Cannabinoid Dependence

Dana E. Selley, Aron H. Lichtman, and Billy R. Martin 199

12 Opioid System Involvement in Cannabinoid Tolerance and Dependence

Rafael Maldonado 221

PART IV. ALCOHOL AND NICOTINE ADDICTION

13 Current Strategies for Identifying Genes for Alcohol Sensitivity

John C. Crabbe 249

14 Genetic Basis of Ethanol Reward

Christopher L. Cunningham and Tamara J. Phillips 263

15 Behavioral and Molecular Aspects of Alcohol Craving and Relapse

Rainer Spanagel 295

16 Molecular and Behavioral Aspects of Nicotine Dependence and Reward

Emilio Merlo Pich, Christian Heidbreder, Manolo Mugnaini, and Vincenzo Teneggi 315

Index 339

Was this article helpful?

0 0

Post a comment