Warfarin Resistance

The widespread use of blood anticoagulants as rodenticides have selected for warfarin resistance in the mouse (24) and rat (25-27). In rodents, warfarin resistance (denoted as Rw in the rat) is inherited as a single autosomal gene with dominant effect. Kohn and Pelz (26) have placed Rw in relation to several positionally mapped gene-anchored microsatellite loci in the rat genome, but the gene is yet to be identified.

Case reports have identified warfarin resistance in humans with transmission that also appears to be autosomal dominant (28). The high plasma levels of warfarin observed in these patients, suggest that the resistance has a pharmacodynamic basis, rather than a pharmacokinetic one. Kohn and Pelz (26) identified homologous regions to Rw on human chromosomes 10q25.3-26, 12q23-q24.3, and 16p13.1-p11 and use positional cloning to identify the putative gene. Once the human gene for warfarin resistance is identified and validated, then it could be used to identify rare patients who have warfarin resistance and who require unusually large warfarin doses to elevate their INR value.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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