Taxanes

In mammalian cells, tubulin is a structurally heterogeneous 100-kDa «13 heterodimer with six a- and seven 1-tubulin isotypes. The antimitotics used in chemotherapy, including taxanes and vinca alkaloids, primarily target 1-I tubulin. Paclitaxel is the prototype of the taxane family of antitumor drugs, which also includes docetaxel. It was the first natural product shown to induce the formation of microtubule bundles in cells, followed by impairment of depolymerization and apoptosis by aberrant mitosis or a multinucleated

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