Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depression because of their efficacy and relatively favorable side-effect profile compared with those of the tricyclic antidepressants. SSRIs act by interfering with the activity of the serotonin transporter (SERT) (49). A number of polymorphisms have been reported in the SERT gene (50-52), and genetic variations in the SERT promoter have been linked to altered functions, such as the association between the short (S) allele (44 bp deletion) of the SERT-PR site and poor response to fluvoxamine and paroxetine in patients treated for major depression (53,54).
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