Promise of Combining Genetic and Clinical Factors to Prevent Bleeding During Warfarin Induction

The associations between genotype, warfarin dose, and hemorrhage during warfarin induction suggest that tailoring the initial warfarin dose based on CYP2C9 genotype might avoid iatrogenic hemorrhages. Several investigators have combined clinical and pharmacogenetic information to estimate the maintenance warfarin dose (Table 2). Loebstein et al. (19) found that the maintenance warfarin dose was correlated with plasma warfarin levels and body surface area (BSA) and inversely correlated with CYP2C9 SNPs, age, and amiodarone use. Tabrizi et al. (14) found that warfarin dose was correlated with weight and inversely correlated with CYP2C9 SNPs and age. Gage et al. (12) found that warfarin dose was correlated with BSA, race, and target INR value and inversely correlated with age and use of amiodarone or simvastatin. Although these studies correlated the maintenance warfarin dose to genotype retrospectively, once validated they can be used to estimate the warfarin prospectively.

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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