Pharmacology and Mechanism of Action

Sulfasalazine consists of sulfapyridine and 5-aminosalicylate (the active component in inflammatory bowel disease). Both components have anti-inflammatory effects (37). Sulfasalazine is highly protein-bound and undergoes N-acetylation in the liver before being excreted via the renal tract. The mechanism of action is unclear and may include effects on B cell, synoviocyte, and endothelial cell proliferation (37). Other mechanisms of action include reduction of cytokines, such as LL1^ and TNFa (37,38). Sulfasalazine is commonly used for the treatment of RA. Recent studies comparing sulfasalazine with other DMARDs have shown efficacy comparable with leflunomide and MTX, with ACR20 responses of between 44% and 59% (10,11).

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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