Pharmacogenetics

Initial studies looked at the effect of sulfoxidation status and toxicity with D-Pa. Emery et al. (46) found a significant association with toxicity and impaired sulfoxidation status in 66 RA patients. Emery also looked at human leukocyte antigen (HLA) associations in these patients and found that HLA-DR3 was associated with toxicity independently of sulfoxidation status. Similarly, Madhok et al. (47) found in a study of 50 RA patients that those with poor sulfoxidation status were 3.9 times more likely to have an adverse event. There was no difference in the two groups in terms of clinical response to D-Pa. Layton et al. (48) investigated the effect of polymorphisms in the glutathione-S-transferase (GST superfamily) on therapeutic outcomes in 81 RA patients. The frequency of the GSTM1 null allele was higher in treatment nonresponders (n = 18) than in responders (72.2% vs. 47.6%; OR 3.94). There was also an association between the haplotype GSTM1 *0/ GSTM3 * A and poor response to D-Pa (OR 7.63).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

Get My Free Ebook


Post a comment