Pharmacogenetics Of Metabolizing Enzymes Cyp450 And Drug Transporter Genes

The cytochrome P450 (CYP450) enzyme system is involved in various metabolic and bio-synthetic processes and constitutes a superfamily of heme enzymes found in most organisms (i.e., bacteria to humans). These enzymes are estimated to account for the biotransformation of approximately 60% of the most commonly prescribed drugs in the United States. A few representative examples are discussed in the following, and additional details on some of these examples (and others) are contained in later chapters.

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