Pharmacogenetic Targets In Central Nervous System Disorders

Although pharmacotherapy in patients with affective disorders has improved the outcome of millions of patients worldwide, medical treatment of mental depression is efficacious in no more than two-thirds of the cases, and there are no biological markers of treatment response. Apart from identification of genomic markers of treatment response, which would constitute an enormous clinical advantage of public health value, the application of pharmacogenmoics may also uncover new targets for the development of novel and hopefully more efficacious drugs with favorable side-effect profile.

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