Pharmacogenetic Determinants of Warfarin Metabolism

In vivo, these SNPs are associated with increased responsiveness to warfarin (9,11-15). Aithal et al. (11) compared controls who required typical warfarin doses to patients whose therapeutic warfarin dose was <10.5 mg/wk. Patients requiring low doses were more likely to have a supratherapeutic INR at the time of warfarin induction and six times more likely to have the CYP2C9*2 or CYP2C9*3 SNPs (9,11). Others found that CYP2C9*3 decreased the selectivity of CYP2C9 for S-warfarin and that amino acid residue 359 is a component of the warfarin-binding site (16,17).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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