Pharmacogenetic Determinants of Warfarin Metabolism

In vivo, these SNPs are associated with increased responsiveness to warfarin (9,11-15). Aithal et al. (11) compared controls who required typical warfarin doses to patients whose therapeutic warfarin dose was <10.5 mg/wk. Patients requiring low doses were more likely to have a supratherapeutic INR at the time of warfarin induction and six times more likely to have the CYP2C9*2 or CYP2C9*3 SNPs (9,11). Others found that CYP2C9*3 decreased the selectivity of CYP2C9 for S-warfarin and that amino acid residue 359 is a component of the warfarin-binding site (16,17).

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