Oral Contraceptive Induced Venous Thromboembolism

Mutations in the coagulation factor V and prothrombin genes are known to be risk factors for venous thromboembolism. The polymorphism in the factor V gene, which has been termed factor V Leiden, comprises a missense mutation (R506Q) due to a G/A transition (G1691A) in exon 10 of the gene (165). The frequency of the polymorphism varies from 2% to 15% in different populations (166). Patients taking oral contraceptives are at higher risk of venous thromboembolism if they are carriers of the factor V Leiden polymorphism (167). The issue of whether to screen women for factor V Leiden before prescribing oral contraceptives remains controversial (166) and is probably not cost-effective. For instance, one episode of venous thromboembolism per year might be prevented by the withdrawal of oral contraceptives from 400 asymptomatic carriers of the factor V Leiden mutation. To identify them, however, approximately 10,000 asymptomatic women need to be tested (168).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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