Long Term Clinical and Laboratory Outcomes with CYP2C9 SNPs

Two studies have found an association between bleeding during warfarin induction and the presence of the CYP2C9*2 and CYP2C9*3 SNPs (9,10). In contrast, Taube et al. (18) found no association between these SNPs and either INR control stability or risk of excessive anticoagulation during long-term treatment. Thus, it seems likely that CYP2C9 genotype (and clinical factors) could be used to estimate the maintenance a priori but that genotyping would not be very helpful in patients who have already found their maintenance dose empirically.

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