Future Research Investigations On Genetic Expression

The completion of the human genome mapping project showed a lower number of genes (25,000-30,000) than expected. This number can hardly explain the differences between humans and others species (99). To explain this apparent discrepancy, it has been hypothesized that evolution depends not only on the number of genes but other genetic phenomena, such as differential expression, RNA editing, and alternative splicing (100,101). These genetic events play an important role in evolution and can have important implications in the efficacy and safety of drugs (i.e., the most common CYP2D6 functional alteration causes a splicing event). Therefore, future pharmacogenomic research will expand from the study of DNA sequence mutation alone to functional alterations in the hope of better understanding the complexity of drug-target interactions and response variability.

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