CYP2C19 is a highly polymorphic enzyme system, with approximately 3% of the Caucasians having allele variation that renders them as slow metabolizers. In contrast, almost 20% of the Asian population carries the slow allele. Allele 9 confers total abolishment of enzymatic activity (13-15). For most pharmacological compounds that are substrates for CYP2C19, this poses a limited problem because the majority of the drugs are metabolized by several CYP450 enzymes. An important exemption is the drug omeprazole, which is only partially metabolized by CYP3A4 and shows up to 12-fold larger area under the concentration-time curve (AUC) in slow versus fast metabolizers (13-15).

Cure Your Yeast Infection For Good

Cure Your Yeast Infection For Good

The term vaginitis is one that is applied to any inflammation or infection of the vagina, and there are many different conditions that are categorized together under this ‘broad’ heading, including bacterial vaginosis, trichomoniasis and non-infectious vaginitis.

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