Application Of Pharmacogenetics In Clinical Gastroenterology And Hepatology

The liver has a complex detoxification system in which several enzymes participate in the metabolism of a large number of xenobiotics. Essentially, all of the major human drug metabolizing enzymes (DMEs) responsible for phase I (modification of functional groups of the xenobiotics) or phase II reactions (conjugation with endogenous substrates) exhibit common polymorphisms at the genomic level (1). The clinical relevance of these polymorphisms depends on how they affect individual susceptibility to disease or response to therapy (efficacy and toxicity). The potential applications of pharmacogenetics in various aspects of clinical gastroenterology and hepatology are summarized in Table 1.

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