Apolipoprotein E

Apart from its role in cardiovascular disease, the apoliprotein E (ApoE) protein has also been associated with late onset and sporadic Alzheimer's disease (AD) (69,70). In the central nervous system (CNS), ApoE plays a key role in mobilization and redistribution of cholesterol and phospholipids during membrane remodeling (70). In a study assessing the influence of the ApoE genotype on therapeutic response to tacrine (acetylcholinesterase inhibitor) in a responder/nonresponder cohort, more than 80% of ApoE4 negative carriers demonstrated marked clinical response to tacrine, as measured by the AD assessment scale (ADAS), whereas ApoE4 positive carriers presented ADAS scores that were worse compared with the baseline levels (69). The ApoE genotype has also been implicated in modulating response to drugs targeting vasopressinergic activity (71). Thus, ApoE is emerging as a potentially useful marker in predicting clinical response to tacrine.

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