Antimalarial Drugs

Antimalarials, such as chloroquine and hydroxychloroquine, are commonly used in the treatment of RA. Although considered to be weaker agents than MTX and sulfasalazine, they are often used in mild disease or in combination with other agents (13). It is known that these drugs accumulate in the acid lysosomes of lymphocytes, macrophages, and polymorphonuclear cells (37,76), where they alter protease function and protein glycosylation. To date there are no studies on genetic polymorphisms and response to antimalarials.

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