Angiotensin Converting Enzyme

Angiotensin-converting enzyme (ACE) plays a critical role in blood pressure regulation. Restenosis after coronary artery stent is a major health problem that is primarily attributed to intimal hyperplasia, which can be attenuated by ACE inhibitors. Identification of patients who are at higher risk of developing restenosis is therefore desirable. In this regard, an insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene has attracted significant attention due to its correlation with serum ACE activity (92). An association was recently reported between carriers of the D allele and reduced risk of restenosis following coronary stenting (93,94).

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