Angiotensin Converting Enzyme Inhibitor Induced Cough

Angiotensin-converting enzyme (ACE) inhibitors have been successfully used in the therapy of hypertension, congestive heart failure, and myocardial infarction (178). However, up to 30% of the treated patients experience a persistent cough, which limits the use of the drug (179,180). Several gene variants have been investigated in the genetic predisposition to ACE-inhibitor induced cough, including the ACE (181,182) and bradykinin B2 receptor (183,184) genes. An insertion/deletion polymorphism in the ACE gene is known to control the plasma ACE level (185,186). However, to date no consistent associations have been identified between the occurrence of cough and polymorphisms in the ACE, bradykinin receptor, and chymase genes (187).

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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