Perspective On Pharmacogenetics In Cardiovascular Medicine

It is clear from the numerous examples reviewed here that genetic polymorphisms can be an important determinant of predicting cardiovascular risk. It is equally clear that these genetic variants determine drug disposition and response in humans. The outcome data with HMGCo-A reductase inhibitors (statins) are particularly interesting in this respect. These studies, conducted in fairly large populations and with specific clinical endpoints (beyond lipid-lowering), focused on the polymorphic genes encoding the proteins, such as APOE, CETP, and stromelysin-1, and showed how the genotype might be associated with worse prognosis.

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