Preclinical Gamma Scintigraphy Imaging Studies

Prior to the introduction in man, in vivo imaging studies are conducted in animals. To perform these studies, rodents are inoculated subcutaneously with cancer cells from various tumor cell lines. Scintigraphic imaging is serially performed at 0.5 to 4 hours after injection of 100 to 300 mCi (mouse and rat) of 99mTc-EC-agents via tail vein. Imaging is performed with a planar gamma camera (Digirad, San Diego, California, U.S.) equipped with a low-energy parallel-hole collimator. The intrinsic spatial resolution is 3 mm and the matrix is 64 x 64.

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