Markers of LHRH Receptor Targets

Gonadotrophin-releasing hormone receptors (GnRH and LHRH) are found in cancers of reproductive tissues, including those of the prostate, ovarian, and breast, and gonadotrophin-releasing hormone can inhibit growth of cell lines derived from such cancers. A radiolabeled LHRH ligand could be useful in diagnosing diseases that produce high levels of LHRH-receptors, such as ovarian cancer, endometriosis, uterine carcinoma, and prostate cancer.

Two prostate cancer cell lines (LNCap: androgen and PSA dependent; PC-3: androgen and PSA independent) were used to evaluate the specificity of 99mTc-EC-LHRH. In vitro cell culture assays indicated that there was more uptake in PC-3 cells (androgen independent) than LNCap cells (androgen dependent) (Fig. 20). Planar imaging studies showed that tumor (LHRH positive) could be imaged with 99mTc-EC-LHRH (Fig. 21).

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment