Thalidomide

EM-12

Fig. 8.1 Structures of thalidomide, EM-12 and their metabolites

Tab. 8.1 Receptors, ion channels and enzymes which are drug targets and show species differences.

Receptors

Adenosine

At, A2

Luteinizing

hormone

LH

Adrenoceptors

a1B' a2A

Muscarinic

M2

Atrial nutriuretic factor

ANF-R1

Neurokinin

NK1, NK3

Bradykinin

B2

Purinoceptors

P2

Cholecystokinin

CCK

Thromboxane

TA2

Dopamine

Di

Vanilloid

Endothelin

ETb

Vasopressin

V1

Serotonin

5-HT1A, B, D

5-HT2, 5-HT3,

5-HT4

Ion Channels

Rapidly activating delayed

rectifier K+ channel

Enzymes

Carboxypeptidase B

Renin

Na+/K+ ATPase

HMG-CoA

reductase

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