Symbols

Clp Clu

Alog P H-bond kel log D7.4 log P pKa T

Plasma clearance

Unbound clearance of free drug

Difference in log P values in octanol and cyclohexane

Hydrogen bond

Elimination rate constant

Distribution coefficient at pH 7.4 (usually octanol/water) Partition coefficient (usually octanol) Ionization constant

Time to maximum observed plasma concentration Unbound volume of distribution of the free drug

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