UCN-01 is a cell-cycle modulator with a number of complex effects resulting in both G1/S arrest and aberrant entry into M phase. These cell-cycle kinetics are associated with an increased p27kip2-cdk2 interaction, Rb hypophosphorylation, and cdkl activation due to chkl inhibition. Phase I trials examined a 72-hour continuous infusion schedule, with dose-limiting toxicities that included nausea, hypotension, hyper-

glycemia, and pulmonary toxicity, and evidence for activity was seen in two patients with melanoma and lymphoma.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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