Skippers Exponential Tumor Growth LogKill Hypothesis

One of the pioneer investigations in tumor growth kinetics was made by Skipper and his colleagues,3 who described the first model of tumor growth kinetics. Despite its flaws and oversimplified nature, the empiric observations derived from this model underlie many of the tenets in cancer chemotherapy. A conclusion derived from his L1210 mouse leukemia model was the exponential (logarithmic) growth of tumor cells. Doubling time of cancer cells was proposed to be constant, yielding a straight line on a semilog plot (Figure 2.1). Another conclusion generated from their experiments was the log-kill hypothesis, which proposes that anticancer drugs act with first-order kinetics, and hence, assuming homogeneous sensitivity to the drug, they will eliminate a constant proportion rather than a constant number of tumor cells regardless of the initial size of the tumor; that is, magnitude of tumor cell kill is a logarithmic function.3 By this a posteriori reasoning, if sufficient drug is given, cure can be achieved when fewer than 1 tumor cell remains. Similarly, therapy against small-volume tumors or micrometastatic disease should be easily successful in effecting cures. However, clinical experience in adjuvant chemotherapy has not borne out this deductive assumption as successfully as hoped.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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