Phase I Oncology Studies

Phase I oncology studies are critical to the development of drugs that fight cancer because they are the primary process by which basic research is translated into clinical applications that could potentially lead to larger clinical trials and effective cancer therapies. There are two fundamental ethical concerns about Phase I cancer research: the risk-benefit ratio and quality of informed consent.30,31,42,54-56 Data regarding the risk-benefit ratio are reviewed here, whereas the data on informed consent in Phase I studies were discussed earlier under the section on informed consent.

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