Pharmacogenetics

One of the important factors affecting antitumor efficacy and clinical toxicity of cancer chemotherapeutic drugs and their complex interaction is an individual's genotype. It has been observed as early as the 1950s that responses to certain drugs may be heritable. The field of pharmacogenetics, which studies the genetic basis for interindividual variability in drug response, classically involved investigations on drug metabolism but currently also encompasses various pharmacoki-netic and pharmacodynamic elements that participate in determining drug response. The ensuing discussion highlights selected pharmacogenetic variables well recognized in current clinical practice of cancer chemotherapy.

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