Mek

m-TOR

Cell cycle Cdk2

Proteosome Histone deacetylase

Apoptosis regulators TRAIL Bcl-2 P53

Caspase XIAP, FLIP Angiogenesis Endothelial cell VEGF

VEGF-R Integrins

Antiestrogen (tamoxifen, fulvestrant), Aromatase inhibitor, LHRH agonist Antiandrogen (flutamide), LHRH agonist

MoAb (cetuximab)

TKI (gefitinib, erlotinib)

MoAb (trastuzumab) TKI (lapatinib, canertinib)

TKI (imatinib)

FTIs (tipifarnib, lonafarnib)

B-RAF Kinase Inhib (BAY43-9006) MEK Kinase Inhib (PD0325901) mTOR Antag (temsirolimus, everolimus)

CDKI (flavopiridol, UCN-01, E7070) Proteosome Inhib (bortezomib) HDACI (FR901228, MS-27-275)

MoAb

Antisense (G3139)

P53 (0NXY-015, INGN201, Nutlin)

Sphingosine kinase (phenoxodiol)

Endo Inhib (thalidomide, TNP-740) Endostatin, angiostatin Antisense

(angiozyme) MoAb (bevacizumab) TKI (SU11248, PTK787) MoAb (2C7) Integrin Inhib (cilengitide) MMPI (marimastat, BAY12-9566)

Approved breast Approved prostate

Approved colon; Phs III H&N, NSCLC. Approved NSCLC;

Phs III breast Approved Breast Phs III breast, renal

Approved CML, GIST

Phs III MDS, CML, breast, NSCLC Phs II Melanoma Phs I

Phs III breast, renal

Phs I

Approved Myeloma Phs I

Phs I

Phs II NHL

Phs II breast, prostate

Approved Colon, phs

II H&N

Phs I

Phs I

Phs I

Phs III NSCLC, gastric

A Disquistion On The Evils Of Using Tobacco

A Disquistion On The Evils Of Using Tobacco

Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.

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