Mechanisms of Immunosuppression in Cancer Patients

Cancers have multiple mechanisms that prevent the activation of, and evade, the immune response, as described next (Table 20.6). It is likely that a therapeutic vaccine may not be an adequate immunotherapy without the means to overcome immunosuppression. With adequate knowledge of how tumors evade T-cell-mediated rejection, strategies are being developed that should improve the efficacy of cancer immunotherapy.

TABLE 20.6. Mechanisms of immunosuppression in cancer patients.

• Downmodulation of MHC

• Tumor-derived immune inhibition (e.g., transforming growth factor (TGF)-beta, IL-10)

• Th2 dominant T-cell response

• APC dysfunction [e.g., as a result of tumor-derived vascular endothelial growth factor (VEGF)]

• Treg cells (including CD25+ CD4+ and CD25-CD4+ cells), both via direct contact and via secreted factors (such as IL-10 and TGF-beta)

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment