Leanne L Seeger and Kambiz Motamedi

Musculoskeletal tumors often present an imaging dilemma to the clinician. This dilemma occurs not only because primary musculoskeletal malignancies are less common than tumors of other organ systems, such as lung or gastrointestinal, but also because of the vast array of possible pathologies reflecting the many different types of mesenchymal tissue. This chapter concentrates on imaging neoplasia of the extremities (see Chapter 58 for Soft Tissue Sarcoma).

It should be kept in mind that distinguishing between benign neoplasia and low-grade malignancy can be challenging, even for the pathologist1; this is especially true for tumors composed of cartilage (enchondroma or osteochondroma versus chondrosarcoma)2,3 and fat (lipoma versus liposar-coma).4 The key to the diagnosis and treatment of muscu-loskeletal neoplasia is best accomplished by a team approach, with close interaction between the oncologist, oncologic surgeon, radiologist, and pathologist.5-7

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