Iv

Stage 4

Stage 4

figure 6.3. Pathophysiology of acute graft-versus-host disease (GVHD). The cytokine theory of acute GVHD pathogenesis involves release of proinflammatory cytokines after conditioning regimen-induced injury, which then leads to stimulation of alloreactive effector cells, which then leads to the further release of cytokines and tissue injury. (Courtesy of J. Antin.)

Conditioning-induced injury

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