Prospective nonrandomized trial

Oral isotretinoin (100mg/m2per day), oral alpha-tocopherol (1,200IU/day), and subcutaneous interferon-a (3 megaunits/m2 twice weekly) for 12 months

A striking difference in response was observed in favor of laryngeal lesions 9/19 [47%] complete response rate at 6 months and 7/14 [50%] at 12 months vs. 1/11 [9%] and 0/7 [0%], respectively, for oral lesions)


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