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Djulbegovic 2000 Multiple Myeloma 136 reported between 29% 59% 12% Commercially sponsored et al.18 1996 and 1998 trials were significantly more likely to favor new innovative therapy arms (74% vs. 26%; P = 0.004). Studies funded by nonprofit organizations showed no difference (53% vs. 47%; P = 0.61)

Djulbegovic 2000 Multiple Myeloma 136 reported between 29% 59% 12% Commercially sponsored et al.18 1996 and 1998 trials were significantly more likely to favor new innovative therapy arms (74% vs. 26%; P = 0.004). Studies funded by nonprofit organizations showed no difference (53% vs. 47%; P = 0.61)

Joffe et al.19 2004 Adult cancers 103 from two U.S. 29% 68% 3% Mean effect size = 1.19

cooperative cancer (95% CI, 1.12-1.27), groups between 1981 favoring innovative and 1995 therapy arm.

ness.2 The published studies have predominantly focused on understanding, by evaluating what research participants understand and what are their motivations (Table 9.3).26,28 Disclosure of information and voluntariness are less well studied.27,29-31

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