Regardless of the site of GIST, differentiation of benign tumors from their malignant counterparts is difficult on CT. Distinguishing between low-grade and high-grade malignant GISTs by CT has been recently reported.46 CT features favoring a diagnosis of high-grade GIST and, associated with poor survival, included large tumor size (larger than 11.1 cm), irregular surface, unclear boundary, mesenteric or bowel wall invasion, heterogeneous enhancement, distant metastases, and peritoneal dissemination.

CT is the most common technique in evaluating hepatic metastases.32,33 These are typically hypodense on unenhanced CT, with occasional hyperdensities resulting from hemorrhage or proteinaceous material. Contrast-enhanced CT metastases are heterogeneous in enhancement, likely because of cystic degeneration. Following treatment with imatinib, metastases to the liver commonly become hypodense, appearing cystlike with a well-defined margin.47,48 Decrease in attenuation of the treated lesions may be due to myxomatous change resulting in small pyknotic nuclei in an eosinophilic myxoid background.49

A Disquistion On The Evils Of Using Tobacco

A Disquistion On The Evils Of Using Tobacco

Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.

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