For detection of hepatic metastases CEAƎ/CIH

89 (intraoperative US)

Specificity >85% Colorectal, gastric, and esophageal cancers

CI, conventional imaging.

regional therapies exist, including chemotherapy administered through the hepatic artery using infusion pumps, selective chemoembolization, radiofrequency ablation, cryoablation, alcohol ablation, and radiolabeled 90Y-microspheres.

Findlay et al.294 showed that, in patients with hepatic metastases, responders can be discriminated from nonre-sponders after 4 to 5 weeks of chemotherapy with fluorouracil by measuring FDG uptake before and during therapy. Some results reported by Vitola et al.,295 Torizuka et al.,296 and Langenhoff et al.,297 showed that 3 weeks after radiofre-quency ablation and cryoablation, 51 of the 56 metastatic sites became FDG negative and there was no recurrence during 16 months follow-up.

Wong et al.298 compared FDG-PET imaging, CT, MRI, and serum levels of CEA to monitor the therapeutic response of hepatic metastases to 90Y-glass microspheres. They found that FDG uptake correlated best with the changes in serum levels of CEA.

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