High Dose Vitamin C

High-dose vitamin C was originally popularized as a cancer therapy by Linus Pauling. His claim that vitamin C potentiated the body's ability to fight off cancer garnered intense public interest and prompted two randomized trials in the late 1970s and early 1980s. Both trials found no difference between vitamin C and placebo, with short survival times regardless of allocation.22,23 Interest in vitamin C as a cancer therapy recurred as researchers argued that early investigations were based on incomplete understanding of the vitamin C mode of action and that the oral doses used were inade-quate.24 Intravenous vitamin C with arsenic is currently under investigation as a treatment for myeloma at Sylvester Cancer Center.25

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