Graft VersusHost Disease

GVHD causes complications after allogeneic HSCT as a direct result of organ damage and as a consequence of infectious complications prompted by GVHD therapy. GVHD can be classified as acute or chronic based on timing of onset and clinical features. Acute GVHD usually develops within the first 2 months of BMT and affects mainly the skin, gastrointestinal (GI) tract, and liver.139 The current standard grading system for acute GVHD is based on the degree of involvement of these three organs (Table 6.2). When pharmacologic immunosup-

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