Cs
Sulindac or Piroxicam
200 mg po bid
(sulindac) or 20 mg po qd (piroxicam) x6
Discontinued due to toxicity in 2; piroxicam more toxic than sulindac; no dramatic adenoma regression
Carbone, 1998115
Step 1 = 12 Step 2 = 31
Steps 1 & 2: CS
Piroxicam
Step 1: 10mg po qd or qod
Step 2: 10mg po qod + DFMO 0.5gm/m2 x 6
Step 1: 10mgqod tolerable; no changes in
ODC or urinary polyamine concentrations Step 2: combination is tolerable; possible synergistic effects
Calaluce, 2000116
A Disquistion On The Evils Of Using Tobacco
Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.
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