Core Needle Biopsy

Core-needle biopsies can be done percutaneously by palpating a mass or lymph node or by radiologic guidance. Core biopsy material yields tissue architecture, including the diagnosis of malignancy, the tissue of origin of the primary tumor, whether a tumor is noninvasive or invasive, and cell-surface receptors. Advantages include the ability to do the biopsy under local anesthesia, minimal scarring, and improved patient tolerance of the procedure. Care should be taken to keep the entry point for the needle in a location that can be incorporated in a definitive resection of the mass in the event the result shows a malignancy (Figure 4.2). A core-needle biopsy when diagnostic can allow planning for either neoad-juvant or adjuvant therapies or for surgical resection. For example, a core-needle biopsy of a large breast mass can allow neoadjuvant chemotherapy of a breast malignancy and possibly downstage the patient to being a breast conservation candidate, particularly when an excisional biopsy would be cosmetically unacceptable and obligate a mastectomy. Thus, it is usually the procedure of choice for making a pathologic diagnosis in many areas of oncology. For large soft tissue tumors or bone lesions, core biopsies should be the first method to consider to obtain a diagnosis.32,33 However, core needle biopsies often do not yield sufficient tissue for making a diagnosis of primary lymphoma, which often requires inci-sional or excisional biopsies.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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