Foreword by Gabriel N. Hortobagyi vii

Preface xiii

Section One Principles of Oncology

1 Evidence-Based Approach to Oncology 3

Emily DeVoto and Barnett S. Kramer

2 Principles of Chemotherapy 14

Grace K. Dy and Alex A. Adjei

3 Principles of Radiation Oncology 41

Timothy J. Kinsella, Jason Sohn, and Barry Wessels

4 Principles of Surgical Therapy in Oncology 58

Michael S. Sabel, Kathleen M. Diehl, and Alfred E. Chang

5 Principles of Targeted and Biological Therapies 73

Stephen R.D. Johnston, Sue Chua, and Charles Swanton

6 Biologic Principles of Hematopoietic Stem

Cell Transplantation 91

Robert J. Soiffer

7 Evaluation of Tumor Markers: An Evidence-Based Guide for Determination of Clinical Utility 106

Daniel F. Hayes

8 Design and Analysis of Oncology Clinical Trials 112

James J. Dignam, Theodore G. Karrison, and John Bryant

9 Ethics of Clinical Oncology Research 127

Manish Agrawal, Lindsay A. Hampson, and Ezekiel J. Emanuel

10 Informatics Infrastructure for Evidence-Based

Cancer Medicine 143

Jeffrey P. Bond and Scott D. Luria

11 Economics of Cancer Care 151

James Khatcheressian and Thomas J. Smith

12 Principles of Screening for Cancer 161

Russell Harris and Linda S. Kinsinger

13 Patient Decision Making 177

Peter A. Ubel

14 Establishing an Interdisciplinary Oncology Team 184

Nathan Levitan, Meri Armour, and Afshin Dowlati

15 Principles of Complementary and Alternative Medicine for Cancer 194

Andrew J. Vickers and Barrie Cassileth

Section Two Translational Basic Science

16 Fundamental Aspects of the Cell Cycle and

Signal Transduction 207

Jeffrey R. Skaar and James A. DeCaprio

17 Viral Carcinogenesis 214

Michele Carbone and Giuseppe Barbanti-Brodano

18 Environmental Carcinogenesis 233

T. Sabo-Attwood, M. Ramos-Nino, and Brooke T. Mossman

19 Cancer Metastasis 244

Kevin McDonnell and Anton Wellstein

20 Tumor Immunology and Immunotherapy 254

Jeffrey Weber, Sophie Dessureault, and Scott Antonia

21 Technologies in Molecular Biology:

Diagnostic Applications 269

Timothy J. Triche

Section Three Cancer Prevention and Control

22 Cancer Epidemiology 287

Melissa L. Bondy and Shine Chang

23 Evidence-Based Cancer Prevention Research: A Multidisciplinary Perspective on Cancer

Prevention Trials 301

Stephen D. Hursting, Michele R. Forman, Asad Umar, Nomeli P. Nunez, and J. Carl Barrett

24 Screening 317

Stephen H. Taplin, Sarah Dash, Paula Zeller, and Jane Zapka

25 Genetic Screening and Counseling for

High-Risk Populations 341

Mary B. Daly

26 Behavior Modification 358

Christopher N. Sciamanna

Section Four Cancer Imaging

27 Central Nervous System Imaging 369

Dima A. Hammoud and Martin G. Pompei

28 Breast Imaging 381

Wendie A. Berg

29 Imaging of Thoracic Malignancies 392

Caroline Chiles and Suzanne L. Aquino

30 Imaging of Gastrointestinal Stromal Tumor 413

Ihab R. Kamel and Elliot K. Fishman

31 Genitourinary Imaging 425

Satomi Kawamoto, Harpreet K. Pannu, David A. Bluemke, and Elliot K. Fishman

32 Musculoskeletal Imaging 442

Leanne L. Seeger and Kambiz Motamedi

33 Positron Emission Tomography and Cancer 449

Daniel N. Chatzifotiadis, Julia W. Buchanan, and Richard L. Wahl

Section Five Solid Tumors

34 Central Nervous System Tumors 487

Ravi D. Rao, Paul D. Brown, Caterina Giannini, Cormac O. Maher, Fredric B. Meyer, Evanthia Galanis, Brad J. Erickson, and Jan C. Buckner

35 Eye, Orbit, and Adnexal Structures 506

Daniel M. Albert, Marni Feldmann, Heather Potter, and Amit Kumar

36 Head and Neck Cancer 528

Ezra E.W. Cohen, Kerstin M. Stenson, Michael Milano, and Everett E. Vokes

37 Lung Cancer 545

Hak Choy, Harvey I. Pass, Rafael Rosell, and Anne Traynor

38 Therapy for Malignant Pleural Mesothelioma 622

Harvey I. Pass, Nicholas Vogelzang, Steven Hahn, and Michele Carbone

39 Mediastinum 645

Alexander S. Krupnick and Joseph B. Shrager

40 Esophageal Cancer 664

John D. Urschel

41 Stomach 680

Scott A. Hundahl, John S. Macdonald, and Stephen R. Smalley

42 Colon, Rectal, and Anal Cancer Management 704

John M. Skibber and Cathy Eng

43 Adenocarcinoma and Other Small Intestinal Malignancies . . . 733

John H. Donohue

44 Cancer of the Liver and Bile Ducts 745

Michael L. Kendrick, Annette Grambihler, Gregory J. Gores, Steven Alberts, and David M. Nagorney

45 An Evidence-Based Approach to the Management of

Pancreatic Cancer 764

Dan Laheru

46 Renal Cell Cancer 782

Joseph I. Clark, Craig Hofmeister, Vicki Keedy, and Jeffrey A. Sosman

47 Ureter, Bladder, Penis, and Urethra 806

Cheryl T. Lee, Brent Hollenbeck, and David P. Wood, Jr.

48 Prostate Cancer 826

Richard Whittington and David J. Vaughn

49 Testis Cancer 844

Timothy Gilligan and Phillip W. Kantoff

50 Cervix, Vulva, and Vagina 874

Julian C. Schink

51 Gestational Trophoblastic Neoplasia 892

John R. Lurain

52 Ovarian Cancer 903

Yukio Sonoda and David Spriggs

53 Uterine Malignancies 928

Gini F. Fleming, Anthony C. Montag, Arno J. Mundt, and S.D. Yamada

54 Evidence-Based Management of Breast Cancer 951

Lisa A. Newman and Daniel F. Hayes

55 Thyroid and Parathyroid 983

Gerard M. Doherty

56 Tumors of the Endocrine System 1005

Jeffrey A. Norton

57 Sarcomas of Bone 1025

Randy N. Rosier and Susan V Bukata

58 Soft Tissue Sarcoma 1039

T. Christopher Windham and Vernon K. Sondak

59 Cutaneous Melanoma 1073

Mark R. Albertini, B. Jack Longley, Paul M. Harari, and Douglas Reintgen

60 Nonmelanoma Cutaneous Malignancies 1093

Montgomery Gillard, Timothy S. Wang, and Timothy M. Johnson

61 Cancer of Unknown Primary Site 1110

F. Anthony Greco and John D. Hainsworth

62 Solid Tumors of Childhood 1124

Crawford J. Strunk and Sarah W. Alexander

Section Six Hematologic Malignancies

63 Acute Myeloid Leukemia and the

Myelodysplastic Syndromes 1151

Jonathan E. Kolitz

64 Acute Lymphoblastic Leukemia 1173

Olatoyosi M. Odenike, Laura C. Michaelis, and Wendy Stock

65 Chronic Lymphocytic Leukemia and Related

Chronic Leukemias 1201

Thomas S. Lin and John C. Byrd

66 Chronic Myeloid Leukemia 1220

Meir Wetzler

67 An Evidence-Based Approach to the Management of

Hodgkin's Lymphoma 1231

Craig H. Moskowitz

68 The Non-Hodgkin's Lymphomas 1247

Andrew D. Zelenetz and Steven Horwitz

69 Multiple Myeloma 1276

Robert L. Schlossman

Section Seven Practice of Oncology

70 Superior Vena Cava Syndrome 1291

Michael S. Kent and Jeffrey L. Port

71 Central Nervous System Emergencies 1299

Kevin P. McMullen, Edward G. Shaw, and Volker W. Stieber

72 Metabolic Emergencies in Oncology 1312

Daniel J. De Angelo

73 Surgical Emergencies 1323

David A. August, Thomas Kearney, and Roderich E. Schwarz

74 Oral Complications of Cancer Therapy 1340

Mark S. Chambers and Adam S. Garden

75 Alopecia and Cutaneous Complications of Chemotherapy . . . . 1354

Faith M. Durden and Paradi Mirmirani

76 Infectious Complications of Cancer Therapy 1363

Safdar Nasia, Christopher J. Crnich, and Dennis G. Maki

77 Acute Toxicities of Therapy: Pulmonary Complications 1401

Scott E. Evans and Andrew H. Limper

78 Cardiac Complications 1411

Maged I. Gharib and Alan K. Burnett

79 Neurologic Complications of Therapy 1418

Kristin Bradley and H. Ian Robins

80 Acute Toxicities of Therapy: Urologic Complications 1426

Sandy Srinivas

81 Issues in Vascular Access with Special Emphasis on the

Cancer Patient 1434

Paul F. Mansfield and David L. Smith

82 Management of Cancer Pain 1446

Donald P. Lawrence, Leonidas C. Goudas, Andrew J. Lipman, Joseph Lau, Rina M. Bloch, and Daniel B. Can

83 Nausea and Vomiting in the Cancer Patient 1473

Paula Gill, Axel Grothey, and Charles Loprinzi

84 Nutritional Support for the Cancer Patient 1488

Lawrence E. Harrison

85 Paraneoplastic Syndromes 1506

Shiiish M. Gadgeel and Antoinette J. Wozniak

86 Malignant Effusions 1518

Shamus R. Carr and Joseph S. Friedberg

87 Evidence-Based Use of Hematopoietic Growth Factors for Optimal Supportive Care of Patients with Cancer 1526

George D. Demetri

88 Management of the Bone Marrow Transplant Patient 1536

Daniel J. Weisdorf and Marcie Tomblyn

89 Management of Anxiety and Depression in Adult Cancer Patients: Toward an Evidence-Based Approach 1552

Paul B. Jacobsen, Kristine A. Donovan, Zoe N. Swaine, and Iryna S. Watson

90 Reproductive Complications and Sexual Dysfunction in the Cancer Patient 1580

Leslie R. Schover

91 The Care of the Terminal Patient 1601

Andrew Putnam

92 Metastatic Cancer to the Central Nervous System 1612

Douglas B. Einstein

93 Metastatic Cancer to Lung 1626

Jessica S. Donington

94 Surgical and Regional Therapy for Liver Metastases 1636

Kenneth K. Tanabe and Sam S. Yoon

95 Metastatic Cancer to Bone 1655

Patrick J. Getty, Jeffrey L. Nielsen, Thomas Huff, Mark R. Robbin, and Beth A. Overmoyer

96 Cancer in the Immunosuppressed Patient 1680

Patrick Whelan and David T. Scadden

97 Cancer in the Older Population 1708

Karim S. Malek and Rebecca A. Silliman

98 Chemotherapy in Patients with Organ Dysfunction 1721

John L. Marshall, Jimmy Hwang, Shakun Malik, and Asim Amin

99 Management of the Pregnant Cancer Patient 1738

Deepjot Singh and Paula Silverman

Section Eight Cancer Survivorship

100 Survivorship Research: Past, Present, and Future 1753

Julia H. Rowland

101 Late Effects of Cancer Treatments 1768

Noreen M. Aziz

102 Medical and Psychosocial Issues in Childhood

Cancer Survivors 1791

Smita Bhatia, Wendy Landier, Jacqueline Casillas, and Lonnie Zeltzer

103 Medical and Psychosocial Issues in Hodgkin's

Disease Survivors 1804

Jon H. Loge and Stein Kaasa

104 Medical and Psychosocial Issues in Testicular

Cancer Survivors 1815

Sophie D. Fossa, Lois B. Travis, and Alvin A. Dahl

105 Medical and Psychosocial Issues in Gynecologic

Cancer Survivors 1828

Karen Basen-Engquist and Diane C. Bodurka

106 Medical, Psychosocial, and Health-Related Quality of Life

Issues in Breast Cancer Survivors 1836

Julie Lemieux, Louise J. Bordeleau, and Pamela J. Goodwin

107 Medical and Psychosocial Issues in Prostate

Cancer Survivors 1859

Tracey L. Krupski and Mark S. Litwin

108 Physical and Psychosocial Issues in Lung

Cancer Survivors 1871

Linda Sarna, Frederic W. Grannis, Jr., and Anne Coscarelli

109 Cancer Survivorship Issues in Colorectal Cancer 1891

Clifford Y. Ko and Patricia A. Ganz

110 Medical and Psychosocial Issues in Transplant Survivors . . . . 1902

Karen L. Syrjala, Paul Martin, Joachim Deeg, and Michael Boeckh

111 Second Malignancies After Radiation Treatment and Chemotherapy for Primary Cancers 1929

Lydia B. Zablotska, Matthew J. Matasar, and Alfred I. Neugut

112 Psychosocial Rehabilitation in Cancer Care 1942

Richard P. McQuellon and Suzanne C. Danhauer

113 Cancer Advocacy 1955

Ellen L. Stovall

Index 1959

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