Clinical Trial Design

Clinical trials aim to identify effective drugs for further studies, while also allowing discontinuation of ineffective drugs in an ethical and efficient way. Traditional phase I/II/III clinical trials for cytotoxic agents assume that (1) the agent will reduce the size of the tumor in a dose-dependent manner;

(2) the agent will have toxicities that are dose dependent; and

(3) reduction in tumor size will lead to improved overall survival and/or improved quality of life. In contrast, newer targeted agents may not have an objective effect on tumor size other than tumor stabilization or metastasis prevention. There may not be a dose-dependent effect, and toxicities may only be modest.113 Consequently, there are limitations in testing target-based agents with conventional trials designed for cytotoxic drugs, and alternative endpoints/trial designs are required.

Herbal Remedy Secret Uncovered

Herbal Remedy Secret Uncovered

Discover How To Use Herbal Medicine Effectively To Heal Away Disease amp illnesses That Most Of The Herbalist Do Not Want You To Know About. If You Have Never Know What Is All About Herbal Medicines amp The Correct Way Of Using Herbs To Build A Healthier Life, Then This Guide Is About To Reveal All Just That.

Get My Free Ebook


Post a comment