Chemotherapeutic Drugs

Anticancer drugs may be subdivided into two large groups based on the dependence of their mechanism of action on the cell cycle (Table 2.2). Cell-cycle-nonspecific drugs, which include alkylating agents and most antitumor antibiotics, kill tumor cells in both the resting and cycling phases. On the other hand, it was previously mentioned that cell-cycle-specific drugs are most effective when tumor cells are

TABLE 2.2. Drugs according to cell-cycle effects.

Cell cycle Agents

TABLE 2.2. Drugs according to cell-cycle effects.

Cell cycle Agents

Cell cycle nonspecific

Nitrogen mustards, aziridines, nitrosoureas, alkyl alkane

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