time figure 8.2. Examples of survival curves exhibiting different failure patterns. Data are generated from hypothetical data with 500 subjects per group. In comparing curves, the Wilcoxon test gives greater weight to earlier failures, whereas the log-rank test weights failures equally throughout follow-up. (A) Curves follow the proportional hazards pattern. The hazard ratio is constant (HR = 2.0). (B) Curves show a violation of proportional hazards, converging over time as the hazard ratio becomes smaller. (C) These curves also are nonproportional, separating later in follow-up.

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