time figure 8.2. Examples of survival curves exhibiting different failure patterns. Data are generated from hypothetical data with 500 subjects per group. In comparing curves, the Wilcoxon test gives greater weight to earlier failures, whereas the log-rank test weights failures equally throughout follow-up. (A) Curves follow the proportional hazards pattern. The hazard ratio is constant (HR = 2.0). (B) Curves show a violation of proportional hazards, converging over time as the hazard ratio becomes smaller. (C) These curves also are nonproportional, separating later in follow-up.

A Disquistion On The Evils Of Using Tobacco

A Disquistion On The Evils Of Using Tobacco

Among the evils which a vitiated appetite has fastened upon mankind, those that arise from the use of Tobacco hold a prominent place, and call loudly for reform. We pity the poor Chinese, who stupifies body and mind with opium, and the wretched Hindoo, who is under a similar slavery to his favorite plant, the Betel but we present the humiliating spectacle of an enlightened and christian nation, wasting annually more than twenty-five millions of dollars, and destroying the health and the lives of thousands, by a practice not at all less degrading than that of the Chinese or Hindoo.

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