Antimetabolites are structurally similar to natural compounds necessary for cell division. They act as competitive substrates for critical purine or pyrimidine nucleoside synthesis pathways. As expected from their mechanism of action through disruption of DNA synthesis, antimetabolites are most effective against tumors with a high growth fraction, and in particular during the S phase. In general, antimetabo-lites are not mutagenic, exhibit a plateau in cytotoxic effect, and require enzymatic conversion to an active form.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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