Auger electron emitter In-111, belonging to group III is cyclotron-produced with a half-life of 2.8 days and decays by electron capture and gamma emission (184 and 296 keV). Its trivalent ion, which has thermodynamic stability, is commonly used for radiolabeling purposes. Advantages include ready availability and well-established use in diagnostic nuclear medicine applications. It is usually chelated to biological molecules using chelating complexes such as diethylene triamine pentaacetic acid (DTPA), ethylenediaminetetraacetic acid (EDTA), or DOTA. It should be noted that because of their slow clearing properties, macrocyclic compounds are preferred for in vivo studies, for example, In-DOTA (36). 111Indium can be effectively chelated using simple techniques either before or after conjugation to a biological molecule usually with the help of a buffer (32,37).

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