Genetic Effects to Offspring

There is no evidence that exposure to radioiodine affects the long-term outcomes of subsequent pregnancies and offspring (59). A 370-MBq (10 mCi) dose of iodine-131 is estimated to deliver a dose of approximately 0.01-0.03 Gy to the ovaries, mostly from excreted RAI in the bladder. Radiation dose can be minimized with hydration and frequent voiding following treatment. Women of child-bearing age should be counseled to refrain from becoming pregnant for at least six months following therapy. This is primarily to confirm treatment response, given that there are significant perinatal risks related to thyrotoxicosis.

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