Progressive activation of Kca channels help terminate the depolarizing phase of activity. The decrease in firing activity within the pool of excitatory interneurons in itself leads to a reduced excitatory drive. The voltage dependence of NMDA channels leads to a progressive closure of these channels due to the gradual hyperpolarization that will ensue. This leads to the regenerative hyperpolarization that, together with the onset of reciprocal inhibition, returns the membrane potential to the inhibitory phase of the cycle of activity. The blockade of KCa channels causes a breakdown of locomotor activity, particularly during slow locomotor activity. All types of Ca2+ channels except L-chan-nels appear to be of importance for pattern generation, and an interference with the Kv 3.4 channel produces severe interference.
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