The Canonical Microcircuit

In light of currently available anatomical and electrophysiological data, we propose that the striatal canonical microcircuit consists of two medium spiny projection neurons (MSN), one fast-spiking (FS) GABAergic interneuron, and one cholinergic neuron (Figure 9.2). The MSNs are GABAergic and receive excitatory glutamatergic inputs at the heads of their spines. An individual MSN possesses about 15,000 spines, and it is estimated that about half of these receive input from cortical terminals (Table 9.1). MSNs are also recipients of other

Group Report: Microcircuits, Molecules, and Motivated Behavior 167 Motor and Cognitive Signals

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