Postexposure prophylaxis

Postexposure prophylaxis is administered to all healthcare workers according to the Public Health Service Statement on the Management of Occupational Exposures to HIV and Recommendations. The policy for postexposure prophylaxis is institution specific and should be available to all employees.

Basic and Expanded Postexposure Prophylaxis Regimens

Regimen Category

Application

Drug Regimen

Basic

Occupational HIV exposures for which there is a recognized transmission risk.

4 week (28 d) of both zidovudine 600 mg every day in divided doses (i.e., 300 mg twice a day, 200 mg three times a day, or 100 mg every 4 h) and lamivudine 150 mg twice a day

Expanded

Occupational HIV exposures that pose an increased risk for transmission (e.g., larger volume of blood and/or higher virus titer in blood)

Basic regimen plus either indinavir 800 mg every 8 hr or nelfinavir 750 mg three times a day

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